雷江涛，助理研究员；1992年生，江西人；

2018年复旦大学博士。

电话：13162533386

邮箱：jiangtaolei@ncu.edu.cn

地址：江西省南昌市红谷滩新区学府大道999号南昌大学前湖校区空间科学与技术研究院

教育经历

2013年9月-2018年6月，复旦大学，物理系，凝聚态物理专业（硕博）。

2009年7月-2013年6月，江西师范大学，物理与通信电子学院，物理学（本科）。

研究与工作经历

2018年9月-至今，南昌大学空间科学与技术研究院，从事生物相关研究。

2015年7月-2015年9月，马里兰州癌症研究所（NCI），交流合作学习。

2014年7月-2014年9月，马里兰州癌症研究所（NCI），交流合作学习。

研究兴趣

研究领域：计算物理生物学

研究方向：蛋白质/多肽的聚集、折叠和解折叠，天然小分子/纳米颗粒调控蛋白质聚集微观机理的计算机模拟研究；

研究意义：蛋白质/多肽的聚集、折叠和解折叠与阿兹海默氏症、帕金森症和渐冻人症等淀粉样疾病相关，甚至与癌症也有着密不可分的关系。因此，对蛋白/多肽的聚集、折叠和解折叠的研究，将有助于了解蛋白质病理性聚集微观机制，为设计疾病相关治疗药物提供线索和理论基础。

发表论文

10. Yibo Jin, Yunxiang Sun,Yujie Chen, Jiangtao Lei, Guanghong Wei*. Molecular dynamics simulations reveal the mechanism of graphene oxide nanosheet inhibition of Aβ1-42 peptide aggregation. Physical chemistry chemical physics. 21(21):10981-10991 (2019). (IF: 3.906)

9. Cuiqin Bai, Dongdong Lin, Yuxiang Mo, Jiangtao Lei, Yunxiang Sun, Luogang Xie, Xinju Yang and Guanghong Wei*. Influence of fullerenol on hIAPP aggregation: amyloid inhibition and mechanistic aspects. Physical chemistry chemical physics. 20(7):4022-4031(2019). (IF: 3.906)

8. Jiangtao Lei, Ruxi Qi, Yegen Tang, Wenning Wang, Guanghong Wei*, Ruth Nussinov, and Buyong Ma*. Conformational stability and dynamics of the cancer-associated isoform ∆133p53β are modulated by p53 peptides and p53-specific DNA. The FASEB Journal, 33(3):4225-4235(2019). (2018). (IF: 5.595)

7. Noam Brown, Jiangtao Lei, Chendi Zhan, Linda J. W. Shimon, Lihi Adler-Abramovich, Guanghong Wei* and Ehud Gazit*. Structural Polymorphism in a Self-Assembled Tri-Aromatic Peptide System. ACS nano. 12(4): 3253-3262 (2018). (IF: 13.709)

6. Yuxiang Mo, Sayanti Brahmachari, Jiangtao Lei, Sharon Gilead, Yiming Tang, Ehud Gazit* and Guanghong Wei*. The inhibitory effect of hydroxylated carbon nanotubes on the aggregation of human islet amyloid polypeptide revealed by a combined computational and experimental study. ACS Chemical Neuroscience,9(11): 2741-2752 (2018). (IF: 4.211)

5. Yibo Jin, Yunxiang Sun, Jiangtao Lei, Guanghong Wei*. Dihydrochalcone molecules destabilize Alzheimer’s amyloid-β protofibrils by disrupting N-terminal β-sheets and D23-K28 salt bridges through binding to the protofibril cavity. Physical chemistry chemical physics. 20(25):17208-17217 (2018). (IF: 3.906)

4. Yujie Chen, Zihan Chen, Yunxiang Sun, Jiangtao Lei, Guanghong Wei*. Mechanistic Insights into the Inhibition and Size effects of Graphene Oxide Nanosheets on the Aggregation of an Amyloid-β Peptide Fragment. Nanoscale, 10(19): 8989-8997 (2018). (IF: 7.233)

3. Jiangtao Lei, Ruxi Qi, Luogang Xie, Wenhui Xi, Guanghong Wei*. Inhibitory effect of hydrophobic fullerenes on the β-sheet-rich oligomers of a hydrophilic GNNQQNY peptide revealed by atomistic simulations. RSC Advances, 7(23): 13947-13956 (2017). (IF: 2.936)

2. Jiangtao Lei, Ruxi Qi, Guanghong Wei*, Ruth Nussinov and Buyong Ma*. Self-aggregation and coaggregation of p53 core fragment with its aggregation Gatekeeper variant. Physical Chemistry Chemical Physics, 18(11): 8098-8107 (2016). (IF: 3.906)

1. Yuxiang Mo, Jiangtao Lei, Yunxiang Sun, Qingwen Zhang and Guanghong Wei*. Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation. Scientific Reports, 6: 33076 (2016). (IF: 4.122)